| First Author | Toyama H | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 3 | Pages | 329-39 |
| PubMed ID | 12354385 | Mgi Jnum | J:111535 |
| Mgi Id | MGI:3654378 | Doi | 10.1016/s1074-7613(02)00387-4 |
| Citation | Toyama H, et al. (2002) Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17(3):329-39 |
| abstractText | After immunization with T cell-dependent antigens, the high-affinity B cells selected in germinal centers differentiate into memory B cells or long-lived antibody-forming cells. However, a role for germinal centers in development of these B lineage cells is still controversial. We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the spleen but barely differentiated into long-lived IgG1 antibody-forming cells in the bone marrow. Mutation in the V-heavy gene was null in these memory B cells. Therefore, Bcl6 and germinal center formation are essential for somatic hypermutation, and generation of memory B cells can occur independently of germinal center formation, somatic hypermutation, and Ig class switching. |
