| First Author | Vats R | Year | 2021 |
| Journal | Blood | Volume | 137 |
| Issue | 19 | Pages | 2676-2680 |
| PubMed ID | 33619560 | Mgi Jnum | J:315104 |
| Mgi Id | MGI:6724752 | Doi | 10.1182/blood.2020009779 |
| Citation | Vats R, et al. (2021) P-selectin deficiency promotes liver senescence in sickle cell disease mice. Blood 137(19):2676-2680 |
| abstractText | Sickle cell disease (SCD) is caused by a homozygous mutation in the beta-globin gene, which leads to erythrocyte sickling, vasoocclusion, and intense hemolysis. P-selectin inhibition has been shown to prevent vasoocclusive events in patients with SCD; however, the chronic effect of P-selectin inhibition in SCD remains to be determined. Here, we used quantitative liver intravital microscopy in our recently generated P-selectin-deficient SCD mice to show that chronic P-selectin deficiency attenuates liver ischemia but fails to prevent hepatobiliary injury. Remarkably, we find that this failure in resolution of hepatobiliary injury in P-selectin-deficient SCD mice is associated with the increase in cellular senescence and reduced epithelial cell proliferation in the liver. These findings highlight the importance of investigating the long-term effects of chronic P-selectin inhibition therapy on liver pathophysiology in patients with SCD. |
