| First Author | Qi C | Year | 2015 |
| Journal | Oncotarget | Volume | 6 |
| Issue | 9 | Pages | 6584-96 |
| PubMed ID | 25762641 | Mgi Jnum | J:309313 |
| Mgi Id | MGI:6757297 | Doi | 10.18632/oncotarget.3164 |
| Citation | Qi C, et al. (2015) P-selectin-mediated platelet adhesion promotes tumor growth. Oncotarget 6(9):6584-96 |
| abstractText | Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the beta3 cytoplasmic tail. This activates alphaIIbbeta3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism. |
