| First Author | Yamada S | Year | 1995 |
| Journal | Blood | Volume | 86 |
| Issue | 9 | Pages | 3487-92 |
| PubMed ID | 7579454 | Mgi Jnum | J:29814 |
| Mgi Id | MGI:77332 | Doi | 10.1182/blood.v86.9.3487.bloodjournal8693487 |
| Citation | Yamada S, et al. (1995) Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood 86(9):3487-92 |
| abstractText | P-selectin-mediated rolling is believed to be important in the recruitment of leukocytes to tissue after ischemia-reperfusion injury. The dorsal skin chamber was used to examine differences in the rolling and stable adhesion of circulating leukocytes in subcutaneous (SC) vessels of P-selectin-deficient and age-matched wild-type mice, both under basal conditions and after ischemia-reperfusion. Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal conditions and post-ischemia-reperfusion (P < .05), but was not eliminated by the deletion of the P-selectin gene. No significant difference between P-selectin-deficient and wild-type mice in shear rate or leukocyte-endothelial adhesion was observed up to 24 hours after ischemia-reperfusion. These results show that P-selectin-mediated rolling is not a prerequisite for ischemia-reperfusion-induced leukocyte-endothelial adhesion in the skin. |
