| First Author | Hartwell DW | Year | 1998 |
| Journal | Microcirculation | Volume | 5 |
| Issue | 2-3 | Pages | 173-8 |
| PubMed ID | 9789257 | Mgi Jnum | J:51787 |
| Mgi Id | MGI:1326860 | Citation | Hartwell DW, et al. (1998) Angiogenesis in P- and E-selectin-deficient mice. Microcirculation 5(2-3):173-8 |
| abstractText | OBJECTIVES: Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. METHODS: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin- deficient mice. RESULTS: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin- deficient mice were similar to those of wild-type mice. CONCLUSION: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo. |
