| First Author | Van Kaer L | Year | 1992 |
| Journal | Cell | Volume | 71 |
| Issue | 7 | Pages | 1205-14 |
| PubMed ID | 1473153 | Mgi Jnum | J:3524 |
| Mgi Id | MGI:52037 | Doi | 10.1016/s0092-8674(05)80068-6 |
| Citation | Van Kaer L, et al. (1992) TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell 71(7):1205-14 |
| abstractText | The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules. We have generated mice with a disrupted TAP1 gene using embryonic stem cell technology. TAP1-deficient mice are defective in the stable assembly and intracellular transport of class I molecules and consequently show severely reduced levels of surface class I molecules. These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S. Cells from the TAP1-deficient mice are unable to present cytosolic antigens to class I-restricted cytotoxic T cells. As predicted from the near absence of class I surface expression, TAP1-deficient mice lack CD4-8+ T cells. |
