| First Author | Jabbari A | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 8 | Pages | 4829-33 |
| PubMed ID | 16210583 | Mgi Jnum | J:119057 |
| Mgi Id | MGI:3701058 | Doi | 10.4049/jimmunol.175.8.4829 |
| Citation | Jabbari A, et al. (2005) Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation. J Immunol 175(8):4829-33 |
| abstractText | Memory T cells do not require self-peptide/MHC (spMHC) complexes to survive long term in vivo. However, memory CD4 T cells lose the ability to reject skin grafts when transiently placed in an environment in which these low-level TCR stimulations are absent. Whether or not spMHC alters the ability of CD8 T cells to respond to stimulation in vivo remains unknown. Here, we show that memory CD8 T cells retain the ability to respond to dendritic cell-mediated stimulation after adoptive transfer into either TAP(-/-) (MHC class I-deficient) or wild-type mice. Surprisingly, naive CD8 T cells, which fail to undergo homeostatic proliferation and erode in number in the absence of MHC class I, also retain the ability to respond to dendritic cell-mediated antigenic stimulation for at least 1 wk after transfer into TAP(-/-) mice. These findings suggest a differential requirement for spMHC signals for maintenance of CD8 T cell function and homeostatic proliferation. |
