| First Author | Piper CJM | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 7 | Pages | 1878-1892.e7 |
| PubMed ID | 31722204 | Mgi Jnum | J:293106 |
| Mgi Id | MGI:6445278 | Doi | 10.1016/j.celrep.2019.10.018 |
| Citation | Piper CJM, et al. (2019) Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells. Cell Rep 29(7):1878-1892.e7 |
| abstractText | Regulatory B cells (Bregs) play a critical role in the control of autoimmunity and inflammation. IL-10 production is the hallmark for the identification of Bregs. However, the molecular determinants that regulate the transcription of IL-10 and control the Breg developmental program remain unknown. Here, we demonstrate that aryl hydrocarbon receptor (AhR) regulates the differentiation and function of IL-10-producing CD19(+)CD21(hi)CD24(hi)Bregs and limits their differentiation into B cells that contribute to inflammation. Chromatin profiling and transcriptome analyses show that loss of AhR in B cells reduces expression of IL-10 by skewing the differentiation of CD19(+)CD21(hi)CD24(hi)B cells into a pro-inflammatory program, under Breg-inducing conditions. B cell AhR-deficient mice develop exacerbated arthritis, show significant reductions in IL-10-producing Bregs and regulatory T cells, and show an increase in T helper (Th) 1 and Th17 cells compared with B cell AhR-sufficient mice. Thus, we identify AhR as a relevant contributor to the transcriptional regulation of Breg differentiation. |
