| First Author | Hahn P | Year | 2004 |
| Journal | Cell Death Differ | Volume | 11 |
| Issue | 11 | Pages | 1192-7 |
| PubMed ID | 15272317 | Mgi Jnum | J:134629 |
| Mgi Id | MGI:3789427 | Doi | 10.1038/sj.cdd.4401486 |
| Citation | Hahn P, et al. (2004) Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ 11(11):1192-7 |
| abstractText | Photoreceptors of bax(-/-)bak(-/-) but neither bax(-/-) mice nor bak(-/-) mice are protected from developmental apoptosis, suggesting that bax(-/-)bak(-/-) photoreceptors may also be protected from pathologic apoptosis. To test this possibility, we exposed bax(-/-)bak(-/-) and bax(-/-) mice to bright light, which normally induces photoreceptor death. Photoreceptors in bax(-/-)bak(-/-) mice were protected from death compared to bax(-/-) mice as indicated by a reduction in the number of TUNEL-positive photoreceptor nuclei 24 h following light damage and almost complete preservation of photoreceptors 7 days following light damage. These results provide the first in vivo evidence that combined deficiency of Bax and Bak can rescue cells from a pathologic stimulus more effectively than Bax deficiency and suggest that combined deficiency of Bax and Bak may also protect cells from other insults. |
