| First Author | Schorr K | Year | 1999 |
| Journal | Cancer Res | Volume | 59 |
| Issue | 11 | Pages | 2541-5 |
| PubMed ID | 10363969 | Mgi Jnum | J:55402 |
| Mgi Id | MGI:1337911 | Citation | Schorr K, et al. (1999) Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res 59(11):2541-5 |
| abstractText | The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo. |
