| First Author | Gulinello M | Year | 2008 |
| Journal | Behav Brain Res | Volume | 193 |
| Issue | 2 | Pages | 315-9 |
| PubMed ID | 18611415 | Mgi Jnum | J:139219 |
| Mgi Id | MGI:3807470 | Doi | 10.1016/j.bbr.2008.06.016 |
| Citation | Gulinello M, et al. (2008) Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease. Behav Brain Res 193(2):315-9 |
| abstractText | Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test. |
