| First Author | Natsuaki Y | Year | 2014 |
| Journal | Nat Immunol | Volume | 15 |
| Issue | 11 | Pages | 1064-9 |
| PubMed ID | 25240383 | Mgi Jnum | J:260268 |
| Mgi Id | MGI:6140334 | Doi | 10.1038/ni.2992 |
| Citation | Natsuaki Y, et al. (2014) Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. Nat Immunol 15(11):1064-9 |
| abstractText | It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1alpha (IL-1alpha) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity. |
