| First Author | Tong J | Year | 2002 |
| Journal | Nat Neurosci | Volume | 5 |
| Issue | 2 | Pages | 95-6 |
| PubMed ID | 11788835 | Mgi Jnum | J:109327 |
| Mgi Id | MGI:3628716 | Doi | 10.1038/nn792 |
| Citation | Tong J, et al. (2002) Neurofibromin regulates G protein-stimulated adenylyl cyclase activity. Nat Neurosci 5(2):95-6 |
| abstractText | Neurofibromatosis type 1 (NF1) is a dominant genetic disorder characterized by multiple benign and malignant nervous system tumors, and by learning defects in 45% of children with NF1 mutations. Studies of neurofibromin, the protein encoded by NF1, have focused on its functions in tumorigenesis and regulation of Ras activity; however, Drosophila NF1 regulates both Ras and cyclic AMP (cAMP) pathways. Expression of a human NF1 transgene rescued cAMP-related phenotypes in NF1 mutant flies (small body size and G protein-stimulated adenylyl cyclase (AC) activity defects), and neuropeptide- and G protein-stimulated AC activity were lower in Nf1-/- as compared to Nf1+/- mouse brains, demonstrating that neurofibromin regulates AC activity in both mammals and flies. |
