| First Author | Pan Y | Year | 2018 |
| Journal | Genes Dev | Volume | 32 |
| Issue | 7-8 | Pages | 491-496 |
| PubMed ID | 29632086 | Mgi Jnum | J:272624 |
| Mgi Id | MGI:6284247 | Doi | 10.1101/gad.310797.117 |
| Citation | Pan Y, et al. (2018) Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth. Genes Dev 32(7-8):491-496 |
| abstractText | Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (Nf1) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, we show that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth. Impaired Ccr2 and Ccl5 expression in athymic microglia/macrophages was restored by T-cell exposure, establishing T-cell-microglia/macrophage interactions as critical stromal determinants that support NF1 LGG growth. |
