| First Author | Arostegui M | Year | 2022 |
| Journal | Nat Commun | Volume | 13 |
| Issue | 1 | Pages | 4989 |
| PubMed ID | 36008423 | Mgi Jnum | J:327968 |
| Mgi Id | MGI:7334277 | Doi | 10.1038/s41467-022-32695-1 |
| Citation | Arostegui M, et al. (2022) Cellular taxonomy of Hic1(+) mesenchymal progenitor derivatives in the limb: from embryo to adult. Nat Commun 13(1):4989 |
| abstractText | Tissue development and regeneration rely on the cooperation of multiple mesenchymal progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in multiple adult tissues. Here, we describe the embryonic origin of appendicular Hic1(+) MPs and demonstrate that they arise in the hypaxial somite, and migrate into the developing limb at embryonic day 11.5, well after limb bud initiation. Time-resolved single-cell-omics analyses coupled with lineage tracing reveal that Hic1(+) cells generate a unique MP hierarchy, that includes both recently identified adult universal fibroblast populations (Dpt(+), Pi16(+) and Dpt(+) Col15a1(+)) and more specialised mesenchymal derivatives such as, peri and endoneurial cells, pericytes, bone marrow stromal cells, myotenocytes, tenocytes, fascia-resident fibroblasts, with limited contributions to chondrocytes and osteocytes within the skeletal elements. MPs endure within these compartments, continue to express Hic1 and represent a critical reservoir to support post-natal growth and regeneration. |
