| First Author | McEvoy J | Year | 2011 |
| Journal | Cancer Cell | Volume | 20 |
| Issue | 2 | Pages | 260-75 |
| PubMed ID | 21840489 | Mgi Jnum | J:176061 |
| Mgi Id | MGI:5288270 | Doi | 10.1016/j.ccr.2011.07.005 |
| Citation | McEvoy J, et al. (2011) Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell 20(2):260-75 |
| abstractText | It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a century. Here, we report that human and mouse retinoblastomas have molecular, cellular, and neurochemical features of multiple cell classes, principally amacrine/horizontal interneurons, retinal progenitor cells, and photoreceptors. Importantly, single-cell gene expression array analysis showed that these multiple cell type-specific developmental programs are coexpressed in individual retinoblastoma cells, which creates a progenitor/neuronal hybrid cell. Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro. |
