| First Author | Mulroy T | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 4 | Pages | 967-71 |
| PubMed ID | 11920562 | Mgi Jnum | J:75999 |
| Mgi Id | MGI:2178195 | Doi | 10.1002/1521-4141(200204)32:4<967::AID-IMMU967>3.0.CO;2-6 |
| Citation | Mulroy T, et al. (2002) Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol 32(4):967-71 |
| abstractText | Thymic primordium, formed by cells derived from the endoderm, the ectoderm and the neural crest-derived mesenchyme, receive fetal liver derived lymphoid precursors. Reciprocal cell-cell interactions between thymic stromal cells and lymphoid precursors are critical in the expansion and maturation of thymocytes. Transcription factor TCF-1 is critical for the expansion of thymocytes becausedeletion of TCF-1 results in a significant decrease in the number of thymocytes without affecting the developmental pattern. In this report we show that Wnt-1 and Wnt-4 are expressed in the thymus and the deletion of Wnt-1 or Wnt-4 result in a substantial decrease in the number of thymocytes without affecting the pattern of maturation. Wnt-1 and Wnt-4 both regulate developing thymocytes because a double deficiency results in a significantly greater decrease of immature and mature thymocytes compared to deficiency in either Wnt-1 or Wnt-4. |
