| First Author | Brisken C | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 6 | Pages | 650-4 |
| PubMed ID | 10733525 | Mgi Jnum | J:61384 |
| Mgi Id | MGI:1354852 | Doi | 10.1101/gad.14.6.650 |
| Citation | Brisken C, et al. (2000) Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 14(6):650-4 |
| abstractText | Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis. |
