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Publication : β-Catenin is essential for Müllerian duct regression during male sexual differentiation.

First Author  Kobayashi A Year  2011
Journal  Development Volume  138
Issue  10 Pages  1967-75
PubMed ID  21490063 Mgi Jnum  J:171430
Mgi Id  MGI:4949952 Doi  10.1242/dev.056143
Citation  Kobayashi A, et al. (2011) {beta}-Catenin is essential for Mullerian duct regression during male sexual differentiation. Development 138(10):1967-75
abstractText  During male sexual differentiation, the transforming growth factor-beta (TGF-beta) signaling molecule anti-Mullerian hormone (AMH; also known as Mullerian inhibiting substance, MIS) is secreted by the fetal testes and induces regression of the Mullerian ducts, the primordia of the female reproductive tract organs. Currently, the molecular identity of downstream events regulated by the AMH signaling pathway remains unclear. We found that male-specific Wnt4 expression in mouse Mullerian duct mesenchyme depends upon AMH signaling, implicating the WNT pathway as a downstream mediator of Mullerian duct regression. Inactivation of beta-catenin, a mediator of the canonical WNT pathway, did not affect AMH signaling activation in the Mullerian duct mesenchyme, but did block Mullerian duct regression. These data suggest that beta-catenin mediates AMH signaling for Mullerian duct regression during male sexual differentiation.
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