| First Author | Yang Q | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 10 | Pages | 1044-50 |
| PubMed ID | 26280998 | Mgi Jnum | J:233391 |
| Mgi Id | MGI:5784583 | Doi | 10.1038/ni.3248 |
| Citation | Yang Q, et al. (2015) TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16(10):1044-50 |
| abstractText | The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ILC lineages, indicating that they are the earliest ILC-committed progenitors identified so far. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate. |
