| First Author | Zhang J | Year | 2022 |
| Journal | Nat Immunol | Volume | 23 |
| Issue | 2 | Pages | 237-250 |
| PubMed ID | 35075279 | Mgi Jnum | J:325396 |
| Mgi Id | MGI:7264832 | Doi | 10.1038/s41590-021-01097-8 |
| Citation | Zhang J, et al. (2022) Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity. Nat Immunol 23(2):237-250 |
| abstractText | Group 2 innate lymphoid cells (ILC2s) are highly heterogeneous tissue-resident lymphocytes that regulate inflammation and tissue homeostasis in health and disease. However, how these cells integrate into the tissue microenvironment to perform tissue-specific functions is unclear. Here, we show neuropilin-1 (Nrp1), which is induced postnatally and sustained by lung-derived transforming growth factor beta-1 (TGFbeta1), is a tissue-specific marker of lung ILC2s. Genetic ablation or pharmacological inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis. Mechanistically, TGFbeta1-Nrp1 signaling enhances ILC2 function and type 2 immunity by upregulating IL-33 receptor ST2 expression. These findings identify Nrp1 as a tissue-specific regulator of lung-resident ILC2s and highlight Nrp1 as a potential therapeutic target for pulmonary fibrosis. |
