| First Author | Gourley T | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 3 | Pages | 377-86 |
| PubMed ID | 10204493 | Mgi Jnum | J:54057 |
| Mgi Id | MGI:1334055 | Doi | 10.1016/s1074-7613(00)80037-0 |
| Citation | Gourley T, et al. (1999) A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Immunity 10(3):377-86 |
| abstractText | Class II transactivator (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells. Surprisingly, when CIITA-/- CD4 T cells were stimulated in the presence of IL-12, they produced not only IFNgamma but also high levels of IL-4. The IL-4 production is due to the accumulation of IL-4 gene transcripts in Th1 cells. This transcriptional control is observed in T cells differentiating to the Th1 but not Th2 lineage, consistent with induction of expression of the CIITA gene in T cells by IFNgamma. Thus, in addition to its role in transactivation of genes involved in antigen presentation, CIITA plays a critical role during the T cell differentiation by negatively regulating the IL-4 gene transcription. |
