| First Author | Wykes M | Year | 2000 |
| Journal | Immunology | Volume | 100 |
| Issue | 1 | Pages | 1-3 |
| PubMed ID | 10809952 | Mgi Jnum | J:110408 |
| Mgi Id | MGI:3640164 | Doi | 10.1046/j.1365-2567.2000.00044.x |
| Citation | Wykes M, et al. (2000) Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology 100(1):1-3 |
| abstractText | Dendritic cells (DC) have recently been shown to play an important role in B-cell function. We have previously shown that DC can capture and retain unprocessed antigen in vitro and in vivo, and can transfer this antigen to naive B cells to initiate antigen-specific antibody responses. We also demonstrated that DC were providing B cells with isotype-switch signals independent of T cells but that T-cell help was essential for antibody production. In this study, using B cells and DC from wild type (WT) and CD40 knockout (CD40KO) mice we show that DC initiate proliferation of B cells independently of CD40, because WT or CD40KO DC could induce proliferation of WT or CD40KO B cells, but proliferation was greater in the absence of CD40. DC also provide B cells with survival signals as WT DC improved viability of B cells after a 5-day culture but survival was reduced in the absence of CD40 expression. |
