| First Author | Bourgeois C | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5589 | Pages | 2060-3 |
| PubMed ID | 12242444 | Mgi Jnum | J:127835 |
| Mgi Id | MGI:3765126 | Doi | 10.1126/science.1072615 |
| Citation | Bourgeois C, et al. (2002) A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297(5589):2060-3 |
| abstractText | The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation. |
