| First Author | Ahonen C | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 5 | Pages | 451-6 |
| PubMed ID | 11967542 | Mgi Jnum | J:76239 |
| Mgi Id | MGI:2178897 | Doi | 10.1038/ni792 |
| Citation | Ahonen C, et al. (2002) The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol 3(5):451-6 |
| abstractText | Affinity maturation of the immune response and the generation of long-lived bone marrow (BM) plasma cells are hallmarks of CD40-dependent, thymus-dependent (TD) humoral immunity. Through disruption of the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-binding site within the CD40 cytoplasmic domain, we selectively ablated affinity maturation and the generation of plasma cells after immunization. Mutagenesis of both the TRAF6 and TRAF2-TRAF3 sites was essential for arresting germinal center formation in response to immunization. CD40-induced B cell proliferation and early immunoglobulin production occurred even when all TRAF sites were ablated. These studies show that specific CD40-TRAF associations control well defined aspects of humoral immunity. In addition, they define the roles that TRAF-dependent and TRAF-independent pathways play in regulating antigen-driven B cell differentiation. |
