| First Author | Schneider A | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 5 | Pages | 554-9 |
| PubMed ID | 10229233 | Mgi Jnum | J:124534 |
| Mgi Id | MGI:3721834 | Doi | 10.1038/8432 |
| Citation | Schneider A, et al. (1999) NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 5(5):554-9 |
| abstractText | The transcription factor NF-kappaB is a regulator of cell death or survival. To investigate the role of NF-kappaB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-kappaB was activated, as determined by increased expression of an NF-kappaB-driven reporter transgene, nuclear translocation of NF-kappaB in neurons and enhanced DNA binding of NF-kappaB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-kappaB in focal ischemia. NF-kappaB may provide a new pharmacological target in neurologic disease. |
