| First Author | Fadda P | Year | 2007 |
| Journal | Biol Psychiatry | Volume | 62 |
| Issue | 3 | Pages | 235-42 |
| PubMed ID | 17161387 | Mgi Jnum | J:129589 |
| Mgi Id | MGI:3769824 | Doi | 10.1016/j.biopsych.2006.08.003 |
| Citation | Fadda P, et al. (2007) Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission. Biol Psychiatry 62(3):235-42 |
| abstractText | BACKGROUND: Basic fibroblast growth factor (FGF2) plays a crucial role during the development of the cerebral cortex. Mice with a knockout of the FGF2 gene have a reduced number of glutamatergic neurons within the deep layers of the cerebral cortex. METHODS: We used molecular and behavioral analyses to investigate possible alterations in corticostriatal function in FGF2 -/- mice. RESULTS: We found that FGF2 deficiency leads to decreased expression of presynaptic markers of integrity for glutamatergic fibers in the striatum, namely the membrane excitatory amino acid transporter 3 (EAAT3) and the vesicular glutamate transporter 1 (VGLUT1). The reduction of corticostriatal glutamatergic function in FGF2 -/- mice is associated with enhanced locomotor activity in a novel environment and increased responsiveness to dopaminergic drugs, such as cocaine or amphetamine. The behavioral alterations of FGF2 -/- can be normalized by injection of a low dose of the dopaminergic agonist apomorphine (.1 mg/kg) that reduces dopamine release by acting on presynaptic receptors. CONCLUSIONS: Our data demonstrate that FGF2 -/- mice have an increased tone and responsiveness of the dopaminergic system and suggest that these animals might represent a model to study disorders that are characterized by an imbalance between glutamatergic and dopaminergic neurotransmission. |
