| First Author | Toivanen R | Year | 2017 |
| Journal | Development | Volume | 144 |
| Issue | 8 | Pages | 1382-1398 |
| PubMed ID | 28400434 | Mgi Jnum | J:240534 |
| Mgi Id | MGI:5887138 | Doi | 10.1242/dev.148270 |
| Citation | Toivanen R, et al. (2017) Prostate organogenesis: tissue induction, hormonal regulation and cell type specification. Development 144(8):1382-1398 |
| abstractText | Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation. |
