| First Author | Oikawa D | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 5 | Pages | 1066-70 |
| PubMed ID | 20146926 | Mgi Jnum | J:157925 |
| Mgi Id | MGI:4437363 | Doi | 10.1016/j.febslet.2010.02.012 |
| Citation | Oikawa D, et al. (2010) Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes. FEBS Lett 584(5):1066-70 |
| abstractText | Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Recently, we showed that the IRE1alpha-XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1alpha- or XBP1-regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1alpha-XBP1 pathway. Moreover, PSG genes, which also belong to the CEA family, were up-regulated by XBP1. We have therefore identified a new aspect of the physiological function of the IRE1alpha-XBP1 pathway in the placenta. |
