| First Author | Pattyn A | Year | 2006 |
| Journal | Dev Biol | Volume | 295 |
| Issue | 1 | Pages | 67-75 |
| PubMed ID | 16677628 | Mgi Jnum | J:110707 |
| Mgi Id | MGI:3640903 | Doi | 10.1016/j.ydbio.2006.03.008 |
| Citation | Pattyn A, et al. (2006) Delays in neuronal differentiation in Mash1/Ascl1 mutants. Dev Biol 295(1):67-75 |
| abstractText | The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More commonly, though, it only partially impairs its generation. The modalities of this partial effect have rarely been documented in any detail. Here, we report a novel function for the bHLH transcription factor Ascl1/Mash1 in the generation of the nucleus of the solitary tract (nTS). In Mash1(-/-) late embryos, the nTS is markedly atrophic. Tracing back the origin of this atrophy, we show that nTS precursors appear in the mutants 1 day later than in the wild type and then accumulate at a slower pace. We also show that the previously reported atrophy of the sympathetic chain in Mash1 mutants is similarly preceded by a delay of 1 to 2 days in the appearance of differentiated ganglionic cells. Finally, we provide evidence that the acceleration imposed by Mash1, regardless of the production of post-mitotic cells, affects differentiation itself, both generic and type-specific. |
