| First Author | Nonogaki K | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 378 |
| Issue | 2 | Pages | 249-54 |
| PubMed ID | 19017526 | Mgi Jnum | J:143072 |
| Mgi Id | MGI:3822718 | Doi | 10.1016/j.bbrc.2008.11.031 |
| Citation | Nonogaki K, et al. (2009) Novel modulators for body weight changes induced by fasting and re-feeding in mice. Biochem Biophys Res Commun 378(2):249-54 |
| abstractText | Catch-up weight gain after malnutrition is a risk factor for metabolic syndrome. Here we show that social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. These effects of social isolation on weight gain were not associated with significant changes in daily average food consumption. Under the same housing condition, genetic deletion of beta-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of beta-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of beta-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice. |
