| First Author | Swann JB | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 25 | Pages | 6382-5 |
| PubMed ID | 19234138 | Mgi Jnum | J:150094 |
| Mgi Id | MGI:3849668 | Doi | 10.1182/blood-2009-01-198564 |
| Citation | Swann JB, et al. (2009) Type I natural killer T cells suppress tumors caused by p53 loss in mice. Blood 113(25):6382-5 |
| abstractText | CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking either type I NKT cells (TCR Jalpha18(-/-)) or all CD1d-restricted T cells (CD1d(-/-)). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development. |
