| First Author | Luo J | Year | 2023 |
| Journal | Immunity | Volume | 56 |
| Issue | 7 | Pages | 1533-1547.e7 |
| PubMed ID | 37354904 | Mgi Jnum | J:338437 |
| Mgi Id | MGI:7511352 | Doi | 10.1016/j.immuni.2023.06.001 |
| Citation | Luo J, et al. (2023) Lipids regulate peripheral serotonin release via gut CD1d. Immunity 56(7):1533-1547.e7 |
| abstractText | The crosstalk between the immune and neuroendocrine systems is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones and neurotransmitters release in response to environmental cues, such as self-lipids and microbial lipids. We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis. We also demonstrated that inhibitory sphingolipids from symbiotic microbe Bacteroides fragilis represses 5-HT release. Mechanistically, CD1d ligation on EC cells transduced a signal and restrained potassium conductance through activation of protein tyrosine kinase Pyk2, leading to calcium influx and 5-HT secretion. Together, our data reveal that by engaging with iNKT cells, gut chemosensory cells selectively perceive lipid antigens via CD1d to control 5-HT release, modulating intestinal and systemic homeostasis. |
