| First Author | DeLustro FA | Year | 1983 |
| Journal | Cell Immunol | Volume | 81 |
| Issue | 1 | Pages | 175-9 |
| PubMed ID | 6604585 | Mgi Jnum | J:7185 |
| Mgi Id | MGI:55656 | Doi | 10.1016/0008-8749(83)90223-x |
| Citation | DeLustro FA, et al. (1983) Delayed-type hypersensitivity to elastase-soluble lung peptides in the tight-skin (Tsk) mouse. Cell Immunol 81(1):175-9 |
| abstractText | The development of immunity to homologous connective tissue antigens was studied with respect to aging in the tight-skin (Tsk) mouse mutant. A delayed-type hypersensitivity (DTH) response to elastase-solubilized lung peptides in Tsk/+ mice, which became evident at 10 weeks of age and increased in intensity until 22 weeks, was observed. Tsk mice did not demonstrate significant DTH responses when challenged with type I or IV collagen, and normal (+/+) littermates of all ages did not respond to any of the antigens under study. DTH responses could be adoptively transferred to normal +/+ and C57BL/6 mice with spleen cells from 30-week-old Tsk/+ mice; treatment with anti-Thy 1.2 antibodies plus complement significantly reduced the ability of these Tsk/+ cells to transfer DTH reactivity. No antibody activity to the antigens under study could be detected in the sera of Tsk/+ or +/+ mice at any age. These results are discussed with regard to the pathological manifestations observed in the Tsk/+ mutant mouse. |
