| First Author | Green MC | Year | 1973 |
| Journal | Mouse News Lett | Volume | 48 |
| Pages | 34 | Mgi Jnum | J:27521 |
| Mgi Id | MGI:75010 | Citation | Green MC, et al. (1973) Tight skin (Tsk). Mouse News Lett 48:34 |
| abstractText | Full text of MNL contribution: New Mutants and Linkages: 1. Tight skin (Tsk). This dominant mutation was discovered by Mrs. Helen Bunker in the B10.D2(58N) congenic resistant strain in July 1967. Tsk/+ mice look normal up to about 2 months of age but can be recognized by a tightness of the skin felt when grasping a mouse by the scruff of the neck. Mutants can be recognized by about 2 weeks of age and possibly earlier. Older animals develop a pronounced hump in the shoulder region. Histological sections of the skin and viscera indicate that there is probably a generalized hyperplasia of loose connective tissue. The phenotype of Tsk/Tsk mice is not yet known. Tsk is linked to a in Ch 2 with about 16% recombination, in the order Tsk, a, Ra. (M.C. Green, H.0. Sweet) |
