| First Author | Luo X | Year | 1994 |
| Journal | Cell | Volume | 77 |
| Issue | 4 | Pages | 481-90 |
| PubMed ID | 8187173 | Mgi Jnum | J:35576 |
| Mgi Id | MGI:83022 | Doi | 10.1016/0092-8674(94)90211-9 |
| Citation | Luo X, et al. (1994) A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77(4):481-90 |
| abstractText | Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues. |
