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Publication : Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock.

First Author  Zákány J Year  2001
Journal  Cell Volume  106
Issue  2 Pages  207-17
PubMed ID  11511348 Mgi Jnum  J:70547
Mgi Id  MGI:2137767 Doi  10.1016/s0092-8674(01)00436-6
Citation  Zakany J, et al. (2001) Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. Cell 106(2):207-17
abstractText  During development, Hox gene transcription is activated in presomitic mesoderm with a time sequence that follows the order of the genes along the chromosome. Here, we show that Hoxd1 and other Hox genes display dynamic stripes of expression within presomitic mesoderm. The underlying transcriptional bursts may reflect the mechanism that coordinates Hox gene activation with somitogenesis. This mechanism appears to depend upon Notch signaling, as mice deficient for RBPJk, the effector of the Notch pathway, showed severely reduced Hoxd gene expression in presomitic mesoderm. These results suggest a molecular link between Hox gene activation and the segmentation clock. Such a linkage would efficiently keep in phase the production of novel segments with their morphological specification.
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