| First Author | Zakin L | Year | 2000 |
| Journal | Proc Natl Acad Sci U S A | Volume | 97 |
| Issue | 26 | Pages | 14388-93 |
| PubMed ID | 11114168 | Mgi Jnum | J:66476 |
| Mgi Id | MGI:1928537 | Doi | 10.1073/pnas.011513398 |
| Citation | Zakin L, et al. (2000) Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos. Proc Natl Acad Sci U S A 97(26):14388-93 |
| abstractText | The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation. |
