| First Author | Tang SJ | Year | 1998 |
| Journal | Development | Volume | 125 |
| Issue | 10 | Pages | 1877-87 |
| PubMed ID | 9550720 | Mgi Jnum | J:48372 |
| Mgi Id | MGI:1267265 | Doi | 10.1242/dev.125.10.1877 |
| Citation | Tang SJ, et al. (1998) The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125(10):1877-87 |
| abstractText | TGF beta-related factors are critical regulators of vertebrate mesoderm development, However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I receptors and Smad1., These results suggest that Tlx-2 is a downstream target gene for BMP signalling in the primitive streak where BMP-4 and other TGF beta-related factors are expressed. Furthermore, disruption of Tlx-2 function leads to early embryonic lethality. Similar to BMP4 and ALK3 mutants, the mutant embryos display severe defects in primitive streak and mesoderm formation. These experiments thus define a BMP/Tlx-2 signalling pathway that is required during early mammalian gastrulation. |
