| First Author | Bortnick A | Year | 2018 |
| Journal | Eur J Immunol | Volume | 48 |
| Issue | 5 | Pages | 815-821 |
| PubMed ID | 29442367 | Mgi Jnum | J:262955 |
| Mgi Id | MGI:6160606 | Doi | 10.1002/eji.201747229 |
| Citation | Bortnick A, et al. (2018) No strict requirement for eosinophils for bone marrow plasma cell survival. Eur J Immunol 48(5):815-821 |
| abstractText | Lasting antibody responses are maintained by long-lived plasma cells, which are thought to lodge in the BM in specialized survival niches. Eosinophils have been reported to function as a critical component of the BM survival niche where they are thought to provide pro-survival signals to nearby plasma cells. Recent study shows that many BM plasma cells are recently generated and chiefly short-lived cells, raising the possibility that rare plasma cell-eosinophil interactions are a rate-limiting step needed to establish lasting humoral immunity. To address these issues, we examined the impact of eosinophil depletion on short- and long-lived BM plasma cells in the context of antibody responses induced by both T-cell dependent and T-cell independent antigens. Surprisingly, our results failed to support a role for eosinophils in either plasma cell generation or survival. These studies included examination of plasma cell frequencies in mice lacking eosinophils either after antibody-mediated depletion, or due to mutation of the GATA1 locus. |
