| First Author | Schmidt JV | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 16 | Pages | 1997-2002 |
| PubMed ID | 10950864 | Mgi Jnum | J:64037 |
| Mgi Id | MGI:1888623 | Doi | 10.1101/gad.14.16.1997 |
| Citation | Schmidt JV, et al. (2000) The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev 14(16):1997-2002 |
| abstractText | Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes. |
