| First Author | Bruggeman SW | Year | 2005 |
| Journal | Genes Dev | Volume | 19 |
| Issue | 12 | Pages | 1438-43 |
| PubMed ID | 15964995 | Mgi Jnum | J:105559 |
| Mgi Id | MGI:3615850 | Doi | 10.1101/gad.1299305 |
| Citation | Bruggeman SW, et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19(12):1438-43 |
| abstractText | The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to investigate whether Ink4a or Arf is more critical for relaying Bmi1 function in lymphoid cells, neural progenitors, and neural stem cells. We show that Arf is a general target of Bmi1, however particularly in neural stem cells, derepression of Ink4a contributes to Bmi1(-/-) phenotypes. Additionally, we demonstrate haploinsufficient effects for the Ink4a/Arf locus downstream of Bmi1 in vivo. This suggests differential, cell type-specific roles for Ink4a versus Arf in PcG-mediated (stem) cell cycle control. |
