| First Author | Miyashita-Lin EM | Year | 1999 |
| Journal | Science | Volume | 285 |
| Issue | 5429 | Pages | 906-9 |
| PubMed ID | 10436162 | Mgi Jnum | J:56699 |
| Mgi Id | MGI:1342193 | Doi | 10.1126/science.285.5429.906 |
| Citation | Miyashita-Lin EM, et al. (1999) Early neocortical regionalization in the absence of thalamic innervation. Science 285(5429):906-9 |
| abstractText | There is a Long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx- 2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the Lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions. |
