| First Author | Wilson DB | Year | 1975 |
| Journal | Teratology | Volume | 11 |
| Issue | 1 | Pages | 87-98 |
| PubMed ID | 1138408 | Mgi Jnum | J:5544 |
| Mgi Id | MGI:54021 | Doi | 10.1002/tera.1420110111 |
| Citation | Wilson DB, et al. (1975) Surface defects in ventricular cells of brains of mouse embryos homozygous for the Loop-tail gene: scanning electron microscopic study. Teratology 11(1):87-98 |
| abstractText | Luminal surfaces in the mesencephalon and rhombencephalon in normal mouse embryos and those homozygous for Lopp-tail were studied by means of scanning electron microscopy. Ventricular cells in the ventrolateral regions of normal day-10 and -11 brains showed single apical cilia and microvilli, whereas those in ventromedial regions showed a dense network of microvilli and bulbous projections which tended to obscure the apical cilia and cellular outlines. Similar regional differences occurred in the Loop-tail brains, although there was a marked decrease in the number and density of microvilli and bulbous projections. At days 12-14 of gestation the latter brains also showed a flattening of cell surfaces, shallow depressions, and craterlike ruptures in the plasma membranes. |
