| Primary Identifier | MGI:1857648 | Allele Type | Spontaneous |
| Gene | Ighmbp2 | Inheritance Mode | Recessive |
| Strain of Origin | BKS.Cg-Dock7<m> +/+ Lepr<db>/J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | An A-to-G transition mutation in intron 4 results in the creation of a cryptic splice site and interferes with the normal splicing of the transcript. RT-PCR analysis on RNA derived from various tissues of homozygous mice demonstrated that approximately 20-25% of the transcripts were spliced normally, while 75-80% of the transcripts were spliced aberrantly. This allele also presents with a deletion of one of the two leucine codons at position 362 and 363 in exon 8 (SW:P40694). |
