| First Author | Rodrigues PF | Year | 2018 |
| Journal | Nat Immunol | Volume | 19 |
| Issue | 7 | Pages | 711-722 |
| PubMed ID | 29925996 | Mgi Jnum | J:282415 |
| Mgi Id | MGI:6380852 | Doi | 10.1038/s41590-018-0136-9 |
| Citation | Rodrigues PF, et al. (2018) Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells. Nat Immunol 19(7):711-722 |
| abstractText | Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R(+) lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH(+)Ly6D(+) precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R(+) lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen. |
