| First Author | Fox GB | Year | 1998 |
| Journal | J Neurosci Res | Volume | 53 |
| Issue | 6 | Pages | 718-27 |
| PubMed ID | 9753199 | Mgi Jnum | J:49970 |
| Mgi Id | MGI:1289638 | Doi | 10.1002/(SICI)1097-4547(19980915)53:6<718::AID-JNR9>3.0.CO;2-8 |
| Citation | Fox GB, et al. (1998) Traumatic brain injury causes delayed motor and cognitive impairment in a mutant mouse strain known to exhibit delayed Wallerian degeneration. J Neurosci Res 53(6):718-27 |
| abstractText | Delayed Wallerian degeneration after neuronal injury is a feature of the C57BL/Wld(S) mouse mutant. In the present study, we examined the effect of unilateral controlled cortical impact (CCI) on motor and cognitive performance in C57BL/6 and C57BL/Wld(S) mice. Performance on a beam- walking task was impaired in both injured groups over the first 3 weeks; however, between 28 and 35 days post injury, C57BL/6 mice continued to improve whereas C57BL/Wld(S) mice showed increased footfaults, In a spatial learning task, C57BL/WldS animals performed consistently better than C57BL/6 mice when tested 7-10 days and 14-17 days following CCI, C57BL/WldS mice also demonstrated improved working memory performance as compared with C57BL/6 mice when trained on days 21-22 after injury; this effect was lost on days 23 and 24, and was not evident in other animals tested in the same task at 28-31 days following injury, These results indicate a marked delay in motor and cognitive impairment following CCI in C57BL/Wld(S) mice compared with injured C57BL/6 controls. This is consistent with previous work showing delayed temporal evolution of neuronal degeneration in C57BL/Wld(S) mice and suggests CCI may be a suitable model for examining the functional consequences of traumatic brain injury (TBI) in genetically altered mice, (C) 1998 Wiley-Liss, Inc. |
