| First Author | Makiyama Y | Year | 1997 |
| Journal | Exp Neurol | Volume | 148 |
| Issue | 1 | Pages | 215-21 |
| PubMed ID | 9398463 | Mgi Jnum | J:44423 |
| Mgi Id | MGI:1100199 | Doi | 10.1006/exnr.1997.6638 |
| Citation | Makiyama Y, et al. (1997) Hydrocephalus in the Otx2+/- mutant mouse. Exp Neurol 148(1):215-21 |
| abstractText | Mice with the Otx2+/- mutation often die during the postneonatal period. Before death these animals, generated from TT2 ES cells and crossed with CBA mice, develop a dome-shaped head, weakness of the limbs, kyphosis, lethargy, drowsiness, and emaciation. Autopsy of these mice revealed eminent dilatation of lateral ventricles and a ballooned cerebrum. Histological analysis shows edematous change of the periventricular white matter. These results suggest that Otx2 functions as a head organizer, and a mutation of this gene is a likely cause of hydrocephalus in mammals. Additionally, craniobasal skeletal anomaly in half of the heterozygotes and dwarfism in some of the female heterozygotes are described. |
