| First Author | Hatley ME | Year | 2010 |
| Journal | Cancer Cell | Volume | 18 |
| Issue | 3 | Pages | 282-93 |
| PubMed ID | 20832755 | Mgi Jnum | J:164198 |
| Mgi Id | MGI:4830895 | Doi | 10.1016/j.ccr.2010.08.013 |
| Citation | Hatley ME, et al. (2010) Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18(3):282-93 |
| abstractText | Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is increased and predicts poor survival in NSCLC. Although miR-21 function has been studied in vitro with cancer cell lines, the role of miR-21 in tumor development in vivo is unknown. We utilize transgenic mice with loss-of-function and gain-of-function miR-21 alleles combined with a model of NSCLC to determine the role of miR-21 in lung cancer. We show that overexpression of miR-21 enhances tumorigenesis and that genetic deletion of miR-21 partially protects against tumor formation. MiR-21 drives tumorigenesis through inhibition of negative regulators of the Ras/MEK/ERK pathway and inhibition of apoptosis. |
