| First Author | Blasco RB | Year | 2011 |
| Journal | Cancer Cell | Volume | 19 |
| Issue | 5 | Pages | 652-63 |
| PubMed ID | 21514245 | Mgi Jnum | J:172200 |
| Mgi Id | MGI:5004991 | Doi | 10.1016/j.ccr.2011.04.002 |
| Citation | Blasco RB, et al. (2011) c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma. Cancer Cell 19(5):652-63 |
| abstractText | We have investigated the role of individual members of the Raf/Mek/Erk cascade in the onset of K-Ras oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation of Erk1 or Erk2 in K-Ras oncogene-expressing lung cells had no significant effect due to compensatory activities. Yet, elimination of both Erk kinases completely blocked tumor development. Similar results were obtained with Mek kinases. Ablation of B-Raf had no significant effect on tumor development. However, c-Raf expression was absolutely essential for the onset of NSCLC. Interestingly, concomitant elimination of c-Raf and B-Raf in adult mice had no deleterious consequences for normal homeostasis. These results indicate that c-Raf plays a unique role in mediating K-Ras signaling and makes it a suitable target for therapeutic intervention. |
